The PCNA antibody - C-terminal region (AVARP03018_T100) from Aviva Systems Biology is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The PCNA antibody - C-terminal region (AVARP03018_T100) has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
PCNA is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome